Category Protein

Evolution of GPCR research

For decades, GPCRs were paradoxical targets: biologically central, yet structurally elusive. These receptors mediate key signaling pathways involved in sensory processing, metabolism, immune function, and neurotransmission. We knew they mattered, but for a long time, many GPCRs were labeled “undruggable”…

Is X-ray crystallography nearing the end?

Is X-ray crystallography nearing the end of its era in membrane protein drug discovery?With cryo-EM rapidly evolving and delivering atomic-resolution structures of membrane proteins that were once considered uncrystallizable, the field is shifting … fast. More and more we hear…