Accelerating
Drug Discovery Together
Structural Biology CRO & Crystallography
GIOS Biostructures is a structural biology CRO that offers a fully integrated service for structure determination, fragment based screening, de novo protein design and protein engineering. Using our automated X-ray crystallography platform, we can accelerate your research towards novel therapeutics, biomarkers and innovative drug discovery solutions.
Service packages
Gene to protein

Starting from a gene or protein sequence, we cover cloning, expression and purification, resulting in a highly pure protein product.
Protein to structure

We deliver high-quality X-ray data and structures through our automated X-ray crystallography platform and synchrotron access.
Fragment-based screening

We offer small-scale X-ray based fragment screening to assess protein druggability and discover druggable sites, including cryptic pockets.
AI-based protein design

.
Complete pipeline of services
Our company offers a complete pipeline of services necessary to determine protein structures — from concept to final model. The process begins with a target protein or an idealized scaffold, which can be engineered using AI-driven methods and converted into a corresponding nucleotide sequence. This gene is then introduced into a suitable cellular system for protein expression. Our Protein-to-Structure workflow enables the production of milligram-scale quantities of protein, optimized for crystallization using our high-throughput platform. Finally, the resulting structures are delivered to the customer.

Latest posts
Design. Predict. Validate. Realize. The MESO™ Advantage.
Protein design/engineering has entered a new era, fueled by the...
Read MoreProtein engineering and de novo protein design — Design, engineer, express and solve
At GIOS Biostructures, we don’t just study proteins, we design...
Read MoreFragment-based screening — big impact from small molecules
Fragment-based screening is a powerful approach to early-stage drug discovery,...
Read MoreFrom protein to structure — precision at every step
At GIOS Biostructures, we take purified proteins and deliver high-resolution...
Read More